Upstream Bio

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About UPB

Upstream Bio, Inc. is a clinical-stage biotechnology company, which engages in the development of treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It develops verekitug, the only known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin. 

CEO
E. Rand Sutherland
CEOE. Rand Sutherland
Employees
52
Employees52
Headquarters
Waltham, Massachusetts
HeadquartersWaltham, Massachusetts
Founded
2021
Founded2021
Employees
52
Employees52

UPB Key Statistics

Market cap
1.62B
Market cap1.62B
Price-Earnings ratio
-12.40
Price-Earnings ratio-12.40
Dividend yield
Dividend yield
Average volume
557.20K
Average volume557.20K
High today
$30.27
High today$30.27
Low today
$28.36
Low today$28.36
Open price
$29.09
Open price$29.09
Volume
519.97K
Volume519.97K
52 Week high
$33.00
52 Week high$33.00
52 Week low
$5.14
52 Week low$5.14

Stock Snapshot

With a market cap of 1.62B, Upstream Bio(UPB) trades at $29.93. The stock has a price-to-earnings ratio of -12.40.

On 2025-12-18, Upstream Bio(UPB) stock moved within a range of $28.36 to $30.27. With shares now at $29.93, the stock is trading +5.5% above its intraday low and -1.1% below the session's peak.

Trading volume for Upstream Bio(UPB) stock has reached 519.97K, versus its average volume of 557.2K.

The stock's 52-week range extends from a low of $5.14 to a high of $33.00.

The stock's 52-week range extends from a low of $5.14 to a high of $33.00.

Analyst ratings

100%

of 8 ratings
Buy
100%
Hold
0%
Sell
0%

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