Karyopharm Therapeutics Inc. Common Stock, also called Karyopharm Therapeutics, is an oncology-focused pharmaceutical company dedicated to the discovery, development, and commercialization of novel first-in-class drugs directed against nuclear export and related targets for the treatment of cancer and other major diseases. Read More Its SINE compounds function by binding with and inhibiting the nuclear export protein XPO1 (or CRM1). The firm's lead compound, XPOVIOTM (selinexor), received accelerated approval from the FDA for the treatment of patients with relapsed or refractory multiple myeloma. In addition to single-agent and combination activity against a variety of human cancers, SINE compounds have also shown biological activity in models of neurodegeneration, inflammation, autoimmune disease, certain viruses and wound-healing. It has several investigational programs in clinical or preclinical development. The company was founded by Joseph Araujo, Ronald A. DePinho, Pamela A Silver, Giulio Draetta, Michael G. Kauffman and Sharon Shacham on December 22, 2008 and is headquartered in Newton, MA.